Indian Curry
The key ingredient appears to be turmeric
Eating a curry once or twice a week could help prevent the onset of Alzheimer's disease and dementia, a US researcher suggests.
The key ingredient is curcumin, a component of the spice turmeric.
Curcumin appears to prevent the spread of amyloid protein plaques - thought to cause dementia - in the brain.
But the theory, presented at the Royal College of Psychiatrists' annual meeting, has been given a lukewarm reception by UK experts.
If you have a good diet and take plenty of exercise, eating curry regularly could help prevent dementia
Professor Murali Doraiswamy
Duke University
Amyloid plaques, along with tangles of nerve fibres, are thought to contribute to the degradation of the wiring in brain cells, eventually leading to symptoms of dementia.
Professor Murali Doraiswamy, of Duke University in North Carolina, said there was evidence that people who eat a curry meal two or three times a week have a lower risk of dementia.
He said researchers were testing the impact of higher doses - the equivalent of going on a curry spree for a week - to see if they could maximise the effect.
Animal studies
Professor Doraiswamy told the meeting: "There is very solid evidence that curcumin binds to plaques, and basic research on animals engineered to produce human amyloid plaques has shown benefits."
"You can modify a mouse so that at about 12 months its brain is riddled with plaques.
"If you feed this rat a curcumin-rich diet it dissolves these plaques. The same diet prevented younger mice from forming new plaques.
"The next step is to test curcumin on human amyloid plaque formation using newer brain scans and there are plans for that."
Professor Doraiswamy said a clinical trial was now underway at the University of California, Los Angeles, to test curcumin's effects in Alzheimer's patients.
He said research had also examined turmeric's therapeutic potential for treating conditions such as cancer and arthritis.
Good diet
He stressed that eating a curry could not counter-balance the increased risk of dementia associated with a poor diet.
Indian communities that regularly eat curcumin have a surprisingly low incidence of Alzheimer's disease but we don't yet know why
Dr Susanne Sorensen
Alzheimer's Society
However, he said: "If you have a good diet and take plenty of exercise, eating curry regularly could help prevent dementia."
Professor Doraiswamy predicted it might be possible to develop a curry pill which had the same therapeutic effect.
However, Rebecca Wood, of the Alzheimer's Research Trust, stressed that people would need to eat a lot of curry - over 100g of turmeric curry powder - to get a clinical dose of curcumin.
She said: "Professor Doraiswamy's unpublished research applies only to animal models; his hypothesis has not been confirmed in human clinical trials.
"We look forward to the results of the human curcumin trial at UCLA."
Dr Susanne Sorensen, of the Alzheimer's Society, said: "Indian communities that regularly eat curcumin have a surprisingly low incidence of Alzheimer's disease but we don't yet know why.
"Alzheimer's Society is keen to explore the potential benefits of curcumin in protecting the brain and we are conducting our own research into this area.
"A cheap, accessible and safe treatment could transform the quality of life of thousands of people with the condition."
Showing posts with label Dementia. Show all posts
Showing posts with label Dementia. Show all posts
Saturday, June 6, 2009
Saturday, July 5, 2008
Tofu 'may raise risk of dementia'
Tofu
Tofu is a widely eaten soy product
Eating high levels of some soy products - including tofu - may raise the risk of memory loss, research suggests.
The study focused on 719 elderly Indonesians living in urban and rural regions of Java.
The researchers found high tofu consumption - at least once a day - was associated with worse memory, particularly among the over-68s.
The Loughborough University-led study features in the journal Dementias and Geriatric Cognitive Disorders.
Soy products are a major alternative protein source to meat for many people in the developing world.
This kind of research into the causes of Alzheimer's could lead scientists to new ways of preventing this devastating disease.
Rebecca Wood
Alzheimer's Research Trust
But soy consumption is also on the increase in the west, where it is often promoted as a "superfood".
Soy products are rich in micronutrients called phytoestrogens, which mimic the impact of the female sex hormone oestrogen.
There is some evidence that they may protect the brains of younger and middle-aged people from damage - but their effect on the ageing brain is less clear.
The latest study suggests phytoestrogens - in high quantity - may actually heighten the risk of dementia.
Lead researcher Professor Eef Hogervorst said previous research had linked oestrogen therapy to a doubling of dementia risk in the over-65s.
She said oestrogens - and probably phytoestrogens - tended to promote growth among cells, not necessarily a good thing in the ageing brain.
Alternatively, high doses of oestrogens might promote the damage caused to cells by particles known as free radicals.
A third theory is that damage is caused not by the tofu, but by formaldehyde, which is sometimes used in Indonesia as a preservative.
The researchers admit that more research is required to ascertain whether the same effects are found in other ethnic groups.
However, previous research has also linked high tofu consumption to an increased risk of dementia in older Japanese American men.
Fermented product
Professor David Smith, of the University of Oxford, said tofu was a complex food with many ingredients which might have an impact.
However, he said: "There seems to be something happening in the brain as we age which makes it react to oestrogens in the opposite way to what we would expect."
The latest study also found that eating tempe, a fermented soy product made from the whole soy bean, was associated with better memory.
Professor Hogervorst said the beneficial effect of tempe might be related to the fact that it contains high levels of the vitamin folate, which is known to reduce dementia risk.
"It may be that that the interaction between high levels of both folate and phytoestrogens protects against cognitive impairment."
She also stressed that there was no suggestion that eating tofu in moderation posed a problem.
Rebecca Wood, of the Alzheimer's Research Trust, which funded the study, said more research was needed to pin down the potential risks and benefits of so-called superfoods.
However, she said: "This kind of research into the causes of Alzheimer's could lead scientists to new ways of preventing this devastating disease.
"As over half a million people have Alzheimer's in the UK today, there is a desperate need to find a new prevention or cure."
Tofu is a widely eaten soy product
Eating high levels of some soy products - including tofu - may raise the risk of memory loss, research suggests.
The study focused on 719 elderly Indonesians living in urban and rural regions of Java.
The researchers found high tofu consumption - at least once a day - was associated with worse memory, particularly among the over-68s.
The Loughborough University-led study features in the journal Dementias and Geriatric Cognitive Disorders.
Soy products are a major alternative protein source to meat for many people in the developing world.
This kind of research into the causes of Alzheimer's could lead scientists to new ways of preventing this devastating disease.
Rebecca Wood
Alzheimer's Research Trust
But soy consumption is also on the increase in the west, where it is often promoted as a "superfood".
Soy products are rich in micronutrients called phytoestrogens, which mimic the impact of the female sex hormone oestrogen.
There is some evidence that they may protect the brains of younger and middle-aged people from damage - but their effect on the ageing brain is less clear.
The latest study suggests phytoestrogens - in high quantity - may actually heighten the risk of dementia.
Lead researcher Professor Eef Hogervorst said previous research had linked oestrogen therapy to a doubling of dementia risk in the over-65s.
She said oestrogens - and probably phytoestrogens - tended to promote growth among cells, not necessarily a good thing in the ageing brain.
Alternatively, high doses of oestrogens might promote the damage caused to cells by particles known as free radicals.
A third theory is that damage is caused not by the tofu, but by formaldehyde, which is sometimes used in Indonesia as a preservative.
The researchers admit that more research is required to ascertain whether the same effects are found in other ethnic groups.
However, previous research has also linked high tofu consumption to an increased risk of dementia in older Japanese American men.
Fermented product
Professor David Smith, of the University of Oxford, said tofu was a complex food with many ingredients which might have an impact.
However, he said: "There seems to be something happening in the brain as we age which makes it react to oestrogens in the opposite way to what we would expect."
The latest study also found that eating tempe, a fermented soy product made from the whole soy bean, was associated with better memory.
Professor Hogervorst said the beneficial effect of tempe might be related to the fact that it contains high levels of the vitamin folate, which is known to reduce dementia risk.
"It may be that that the interaction between high levels of both folate and phytoestrogens protects against cognitive impairment."
She also stressed that there was no suggestion that eating tofu in moderation posed a problem.
Rebecca Wood, of the Alzheimer's Research Trust, which funded the study, said more research was needed to pin down the potential risks and benefits of so-called superfoods.
However, she said: "This kind of research into the causes of Alzheimer's could lead scientists to new ways of preventing this devastating disease.
"As over half a million people have Alzheimer's in the UK today, there is a desperate need to find a new prevention or cure."
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